Protein Family Models

This domain is found at the C-terminal of FecR [1,2], which adopts a secretin N0-like fold [1]. FecARI are responsible for induction of the ferric citrate uptake system. When ferric citrate binds FecA, a signal is transmitted across the outer membrane to FecR, a cytoplasmic membrane protein that transmits signal across the membrane and activates the sigma-70 family protein FecI [2]. [1]. 32107313. Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria. Jensen JL, Jernberg BD, Sinha SC, Colbert CL;. J Biol Chem. 2020;295:5795-5806. [2]. 10633096. Surface signaling in ferric citrate transport gene induction: interaction of the FecA, FecR, and FecI regulatory proteins. Enz S, Mahren S, Stroeher UH, Braun V;. J Bacteriol. 2000;182:637-646. (from Pfam)

Date:

2024-10-16

FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognises iron dicitrate in the periplasm. [1]. 2254251. Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12. Van Hove B, Staudenmaier H, Braun V;. J Bacteriol 1990;172:6749-6758. (from Pfam)

Date:

2024-10-16