Protein Family Models for Protein (Select 2710827411) - Protein Family Models

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Items: 4

Select item 4127431.

MGMT family protein

This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases [1]. [1]. 8156986. Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli. Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC;. EMBO J 1994;13:1495-1501. (from Pfam)

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Biological Process:: DNA repair (GO:0006281)

Date:: 2024-10-16

Family Accession:: NF013222.5
Method:: HMM

Select item 3900472.

new record, indexing in progress

Family Accession:

Select item 918303.

methylated-DNA--[protein]-cysteine S-methyltransferase

methylated-DNA--[protein]-cysteine S-methyltransferase is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA; it repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme

Date:: 2024-07-03

Family Accession:: 11417447
Method:: Sparcle

Select item 220674.

methylated-DNA--[protein]-cysteine S-methyltransferase

All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).

GO Terms: