This entry represents a linker domain found in polyketide synthases, which connects the N-terminal domains with the B-domain as described in RhiE [1-3]. Paper describing PDB structure 4kc5. [1]. 24048471. Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C;. Nature. 2013;502:124-128. Paper describing PDB structure 4na1. [2]. 24508341. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT;. Structure. 2014;22:444-451. Paper describing PDB structure 4tkt. [3]. 26420866. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B;. Proc Natl Acad Sci U S A. 2015;112:12693-12698. Paper describing PDB structure 5e5n. [4]. 26724270. The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex. Gay DC, Wagner DT, Meinke JL, Zogzas CE, Gay GR, Keatinge-Clay AT;. J Struct Biol. 2016;193:196-205. (from Pfam)
- Date:
- 2024-10-16