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Transcription regulator GlnR, N-terminal domain
This domain is found at the N-terminal end of Transcription regulator GlnR from Amycolatopsis mediterranei and similar sequences predominantly found in actinobacteria. GlnR plays a key role in the global regulation of nitrogen metabolism. It belongs to the OmpR/PhoB subfamily. This domain shows five alternating beta-strands and alpha- helices that form a five-stranded parallel beta-sheet in the middle surrounded by two alpha-helices on one side and three on the other, showing great structure similarity with most of the known structures of the typical RR receiver domains [1]. This domain is usually found associated with Pfam:PF00486. Paper describing PDB structure 4o1h. [1]. 24733389. Atypical OmpR/PhoB subfamily response regulator GlnR of actinomycetes functions as a homodimer, stabilized by the unphosphorylated conserved Asp-focused charge interactions. Lin W, Wang Y, Han X, Zhang Z, Wang C, Wang J, Yang H, Lu Y, Jiang W, Zhao GP, Zhang P;. J Biol Chem. 2014;289:15413-15425. (from Pfam)
winged helix-turn-helix domain-containing protein
winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator
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