Protein Family Models

Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) found almost ubiquitously in the three domains of life (Archaea, Bacteria, and Eukarya). TAL shares a high degree of structural similarity and sequence identity with fructose-6-phosphate aldolase (FSA). They both belong to the class I aldolase family[4]. Their protein structures have been revealed[5]. [1]. 11705376. Snapshots of catalysis: the structure of. fructose-1,6-(bis)phosphate aldolase covalently bound to the. substrate dihydroxyacetone phosphate.. Choi KH, Shi J, Hopkins CE, Tolan DR, Allen KN;. Biochemistry 2001;40:13868-13875.. [2]. 11298760. Identification of catalytically important residues in the active. site of Escherichia coli transaldolase.. Schorken U, Thorell S, Schurmann M, Jia J, Sprenger GA,. Schneider G;. Eur J Biochem 2001;268:2408-2415.. [3]. 10869557. The three-dimensional structure of human transaldolase.. Thorell S, Gergely P Jr, Banki K, Perl A, Schneider G. FEBS Lett 2000;475:205-208.. [4]. 26131847. Converting Transaldolase into Aldolase through Swapping of the. Multifunctional Acid-Base Catalyst: Common and Divergent. Catalytic Principles in F6P Aldolase and Transaldolase.. Sautner V, Friedrich MM, Lehwess-Litzmann A, Tittmann K;. Biochemistry. 2015;54:4475-4486.. [5]. 25267444. Sweet siblings with different faces: the mechanisms of FBP and. F6P aldolase, transaldolase, transketolase and phosphoketolase. revisited in light of recent structural data.. Tittmann K;. Bioorg Chem. 2014;57:263-280. (from Pfam)

Date:

2024-08-14

This small family of proteins is a member of the transaldolase sybfamily represented by PF00923. Coxiella and Staphylococcus lack members of the known transaldolase equivalog families and appear to require a transaldolase activity for completion of the pentose phosphate pathway.

Date:

2021-04-27