Protein Family Models

This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. It contains an evolutionary conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF, the site of interaction with proline-rich peptides. Family members include RME-8 (Required for receptor-mediated endocytosis 8), a DNAJC13 protein. RME-8 was first identified as a protein that is required for endocytosis in Caenorhabditis elegans. It coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation [1]. Family members found in Arabidopsis include Arabidopsis trithorax-related3 (Atxr3), also known as set domain group 2 (Sdg2). It is the major enzyme responsible for H3K4me3 in Arabidopsis and SDG2-dependent H3K4m3 is critical for regulating gene expression and plant development [2]. Another family member found in Arabidopsis is Tic56. It is an essential subunit of a 1-MDa protein complex at the inner chloroplast envelope membrane [3]. Furthermore, Tic56 is important for rRNA processing and chloroplast ribosome assembly [4]. [1]. 24643499. RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. Freeman CL, Hesketh G, Seaman MN;. J Cell Sci. 2014;127:2053-2070. [2]. 20937886. SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. Guo L, Yu Y, Law JA, Zhang X;. Proc Natl Acad Sci U S A. 2010;107:18557-18562. [3]. 28125316. Protein import-independent functions of Tic56, a component of the 1-MDa translocase at the inner chloroplast envelope membrane. Agne B, Ko. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.). (from Pfam)

Date:

2024-08-14

RDD family protein with uncharacterized N-terminal domain DUF4339; the RDD domain contains three highly conserved amino acids (one arginine and two aspartates) and two predicted transmembrane regions

Date:

2017-10-26