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cytochrome c maturation protein CcmE
CcmE is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. [1]. 7635817. Escherichia coli genes required for cytochrome c maturation. Thony-Meyer L, Fischer F, Kunzler P, Ritz D, Hennecke H;. J Bacteriol 1995;177:4321-4326. [2]. 7715601. The cycHJKL gene cluser plays an essential role in the biogenesis of c-type cytochromes in Bradyrhizobium japonicum. Ritz D, Thony-Meyer L, Hennecke H;. Mol Gen Genet 1995;247:27-38. (from Pfam)
CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
cytochrome c maturation protein CcmE acts as a heme chaperone required for the biogenesis of c-type cytochromes
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