Protein Family Models

This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity [1]. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli [2]. [1]. 15944459. The TetR family of transcriptional repressors. Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R;. Microbiol Mol Biol Rev. 2005;69:326-356. [2]. 1431248. Growth of Escherichia coli in human urine: role of salt tolerance and accumulation of glycine betaine. Kunin CM, Hua TH, Van Arsdale White L, Villarejo M;. J Infect Dis. 1992;166:1311-1315. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Date:

2024-04-09