Protein Family Models

This is the C-terminal domain found in Bacillus thuringiensis protein Cry35Ab1 (an insecticidal protein). The domain has three helices held in a hydrophobic core, the first two form a typical helix-loop-helix whilst the third helix is perpendicular. The domain is structurally homologous to BinB and proteins containing similar beta-trefoil lectin-like domains. The domain is not required for insecticidal activity or for immuno-reactivity and its function is likely to be to bind to WCR brush border membrane vesicles [1]. [1]. 25390338. Structural and biophysical characterization of Bacillus thuringiensis insecticidal proteins Cry34Ab1 and Cry35Ab1. Kelker MS, Berry C, Evans SL, Pai R, McCaskill DG, Wang NX, Russell JC, Baker MD, Yang C, Pflugrath JW, Wade M, Wess TJ, Narva KE;. PLoS One. 2014;9:e112555. (from Pfam)

Date:

2024-10-16

The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see Pfam:PF02796. [1]. 7628011. Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site. Yang W, Steitz TA;. Cell 1995;82:193-207. (from Pfam)

Date:

2024-10-16

recombinase family protein, which belongs to the serine recombinase family, catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

Date:

2021-09-23