Protein Family Models

This family includes the enzyme 4-oxalocrotonate tautomerase Swiss:Q01468 that catalyses the ketonisation of 2-hydroxymuconate to 2-oxo-3-hexenedioate. [1]. 7966298. Preliminary crystallographic analysis of 4-oxalocrotonate tautomerase reveals the oligomeric structure of the enzyme. Roper DI, Subramanya HS, Shingler V, Wigley DB;. J Mol Biol 1994;243:799-801. (from Pfam)

Date:

2024-10-16

tautomerase family protein similar to Burkholderia lata 4-oxalocrotonate tautomerase that catalyzes the isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers

Date:

2024-11-25

2-hydroxymuconate tautomerase (also called 4-oxalocrotonate tautomerase) is a homohexamer in which each monomer is very small, at about 62 amino acids. Pro-1 of the mature protein serves as a general base. The enzyme functions in meta-cleavage pathways of aromatic hydrocarbon catabolism. Because several Arg residues located near the active site in the crystal structure of Pseudomonas putida are not conserved among all members of this family, because the literature describes a general role in the isomerization of beta,gamma-unsaturated enones to their alpha,beta-isomers, and because some species contain fairly divergent paralogs, the family is regarded as not necessarily uniform in function.

Date:

2024-06-21