The FrsA-like family includes FrsA, an esterase found to have the alpha/beta-hydrolase fold [1,2,3]. t also includes the hydrolytic polyketide shortening protein Ayg1 from fungi [4], 2,6-dihydropseudooxynicotine hydrolase from Paenarthrobacter nicotinovorans [5] and Fus2 from Gibberella species [6]. The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase is involved in the nicotine-degradation pathway of Arthrobacter nicotinovorans [5]. Fus2 is part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Fus2 catalyses closure of the 2-pyrrolidone ring of the intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized by Fus8 [6]. [1]. 30951551. Purification and biochemical characterization of FrsA protein from Vibrio vulnificus as an esterase. Wang X, Li ZM, Li Q, Shi M, Bao L, Xu D, Li Z;. PLoS One. 2019;14:e0215084. [2]. 23452154. Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase. Kellett WF, Brunk E, Desai BJ, Fedorov AA, Almo SC, Gerlt JA, Rothlisberger U, Richards NG;. Biochemistry. 2013;52:1842-1844. [3]. 21623357. FrsA functions as a cofactor-independent decarboxylase to control metabolic flux. Lee KJ, Jeong CS, An YJ, Lee HJ, Park SJ, Seok YJ, Kim P, Lee JH, Lee KH, Cha SS;. Nat Chem Biol. 2011;7:434-436. [4]. 15310761. Hydrolytic polyketide shortening by ayg1p, a novel enzyme involved in fungal melanin biosynthesis. Fujii I, Yasuoka Y, Tsai HF, Chang YC, Kwon-Chung KJ, Ebizuka Y;. J Biol Chem. 2004;279:44613-44620. [5]. 17275835. Structure and action of a C-C bond cle. TRUNCATED at 1650 bytes (from Pfam)
- Date:
- 2024-10-16