Protein Family Models

The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing [1]. [1]. 15055202. NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1. Grynberg M, Godzik A;. Trends Biochem Sci 2004;29:106-110. (from Pfam)

Date:

2024-10-16

The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family. Structure of Swiss:P09980. [1]. 9288744. Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G;. Cell 1997;90:635-647. (from Pfam)

Date:

2024-10-16

nuclease-related domain (NERD)-containing protein has distant similarity to endonucleases and DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

Date:

2024-10-28