This is the central domain of phage integrases. This domain is known to mediate DNA binding and binds to the major groove adjacent to the site of DNA cleavage [1]. It consists of two pairs of antiparallel helices that pack together at nearly a right angle and form a four-helix bundle. Paper describing PDB structure 1p7d. [1]. 12887904. A conformational switch controls the DNA cleavage activity of lambda integrase. Aihara H, Kwon HJ, Nunes-Duby SE, Landy A, Ellenberger T;. Mol Cell. 2003;12:187-198. Paper describing PDB structure 1z19. [2]. 15973401. A structural basis for allosteric control of DNA recombination by lambda integrase. Biswas T, Aihara H, Radman-Livaja M, Filman D, Landy A, Ellenberger T;. Nature. 2005;435:1059-1066. Paper describing PDB structure 2oxo. [3]. 18540053. Crystallization and structure determination of the core-binding domain of bacteriophage lambda integrase. Kamadurai HB, Jain R, Foster MP;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:470-473. Paper describing PDB structure 5j0n. [4]. 27223329. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD;. Elife. 2016; [Epub ahead of print] (from Pfam)
- Date:
- 2024-10-16