Protein Family Models

This domain is found in Staphylococcus aureus collagen-binding surface protein. The structure of the repetitive B-region has been solved [1] and forms a beta sandwich structure. [1]. 10673425. Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein. Deivanayagam CC, Rich RL, Carson M, Owens RT, Danthuluri S, Bice T, Hook M, Narayana SV;. Structure Fold Des 2000;8:67-78. (from Pfam)

Date:

2024-10-29

This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region.

Date:

2021-04-27

LPXTG cell wall anchor domain-containing protein similar to Listeria monocytogenes cell wall protein Lmo2714

Date:

2017-03-02