Protein Family Models

The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement [2]. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected [2]. [1]. 9714164. Structural features of the plasmid pMV158-encoded transcriptional repressor CopG, a protein sharing similarities with both helix-turn-helix and beta-sheet DNA binding proteins. Acebo P, Garcia de Lacoba M, Rivas G, Andreu JM, Espinosa M, del Solar G. Proteins 1998;32:248-261. [2]. 9857196. The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator. Gomis-R th FX, Sol M, Acebo P, Parraga A, Guasch A, Eritja R, Gonzalez A, Espinosa M, del Solar G, Coll M. EMBO J 1998;17:7404-7415. (from Pfam)

Date:

2024-10-16

CopG family ribbon-helix-helix protein may bind DNA and function as a transcriptional regulator, similar to Caulobacter vibrioides orphan antitoxin ParD2, the antitoxin component of a non-functional type II toxin-antitoxin

Date:

2020-08-18