Protein Family Models

This domain is found at the N-terminus of family 92 glycosyl hydrolase proteins. (from Pfam)

Date:

2024-08-14

Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation [1]. [1]. 10026209. Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. Liu Y, Choudhury P, Cabral CM, Sifers RN;. J Biol Chem 1999;274:5861-5867. [2]. 16131397. GH97 is a new family of glycoside hydrolases, which is related to the alpha-galactosidase superfamily. Naumoff DG;. BMC Genomics. 2005;6:112. (from Pfam)

Date:

2024-10-16

This family of glycosyl hydrolases (glycosidases) includes individual members characterized as mannosidases with various fine specificities. Members sometimes occur in large paralogous families, as with the 23 found in Bacteroides thetaiotaomicron VPI-5482, all 22 that could be expressed showing alpha-mannosidase activity.

Date:

2022-03-28

glycoside hydrolase family 92 protein similar to Alteromonas sp. alpha-mannosidase which is involved in the cleavage of the alpha form of mannose

Date:

2024-08-16