Protein Family Models

The structure model of this domain folds into 10 beta strands arranged in two beta sheets as well as 4-5 elongated alpha helices. The beta sheets distantly resemble the Collagen_bind (Pfam:PF05737) domain. It is annotated N-terminal to repeating stalk domains in bacterial surface proteins. This domain can be found on a E. faecalis protein encoded by the EF3314 gene, which was proposed to contribute to the interaction of E. faecalis with the host and to the bacterial virulence [1]. [1]. 19856273. Surface protein EF3314 contributes to virulence properties of Enterococcus faecalis. Creti R, Fabretti F, Koch S, Huebner J, Garsin DA, Baldassarri L, Montanaro L, Arciola CR;. Int J Artif Organs. 2009;32:611-620. (from Pfam)

Date:

2024-10-16

This domain is found in a wide variety of extracellular bacterial proteins often in multiple tandem copies. (from Pfam)

Date:

2024-08-14

This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region.

Date:

2021-04-27