Protein Family Models

This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family [1]. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase [2]. NnrS contributes to nitrosative-stress tolerance in V. cholerae and protects the cellular iron pool from the formation of dinitrosyl iron complexes (DNICs), thus protecting critical metabolic pathways from inhibition [3,4]. [1]. 12618453. Operon structure and regulation of the nos gene region of Pseudomonas stutzeri, encoding an ABC-Type ATPase for maturation of nitrous oxide reductase. Honisch U, Zumft WG;. J Bacteriol 2003;185:1895-1902. [2]. 11882718. Characterization of a member of the NnrR regulon in Rhodobacter sphaeroides 2.4.3 encoding a haem-copper protein. Bartnikas TB, Wang Y, Bobo T, Veselov A, Scholes CP, Shapleigh JP;. Microbiology 2002;148:825-833. [3]. 23935055. A novel protein protects bacterial iron-dependent metabolism from nitric oxide. Stern AM, Liu B, Bakken LR, Shapleigh JP, Zhu J;. J Bacteriol. 2013;195:4702-4708. [4]. 22511349. The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines. Stern AM, Hay AJ, Liu Z, Desland FA, Zhang J, Zhong Z, Zhu J;. mBio. 2012;3:e00013-e00012. (from Pfam)

Date:

2024-10-16

NnrS family protein similar Rhodobacter sphaeroides NnrS, a heme- and copper-containing membrane protein whose expression is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide

Date:

2019-12-11