The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues. [1]. 12514189. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS. subfamily related to Caenorhabditis elegans GON-1.. Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko. S, Wight TN, Leduc R, Apte SS;. J Biol Chem. 2003;278:9503-9513.. [2]. 12562771. Identification and characterization of ADAMTS-20 defines a novel. subfamily of metalloproteinases-disintegrins with multiple. thrombospondin-1 repeats and a unique GON domain.. Llamazares M, Cal S, Quesada V, Lopez-Otin C;. J Biol Chem. 2003;278:13382-13389. (from Pfam)
GO Terms:- Molecular Function:
- metalloendopeptidase activity (GO:0004222)
- Molecular Function:
- zinc ion binding (GO:0008270)
- Date:
- 2024-08-14