Protein Family Models

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 265 amino acids in length. This protein contains a helix-turn-helix motif that is likely to be DNA-binding. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Date:

2024-08-14

This domain contains a predicted helix-turn-helix suggesting a DNA-binding function. (from Pfam)

Date:

2024-08-14

Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1]. [1]. 7801124. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases [see comments]. Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR;. Science 1994;266:1981-1986. (from Pfam)

Date:

2024-10-16

Date:

2021-03-03

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10