Protein Family Models

GSPE is an ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. This entry represents the N1E domain at its N-terminal end which associates with the cytoplasmic domain of the inner membrane protein GspL [1,2]. Paper describing PDB structure 2bh1. [1]. 15843017. The X-ray structure of the type II secretion system complex formed by the N-terminal domain of EpsE and the cytoplasmic domain of EpsL of Vibrio cholerae. Abendroth J, Murphy P, Sandkvist M, Bagdasarian M, Hol WG;. J Mol Biol. 2005;348:845-855. Paper describing PDB structure 4pht. [2]. 25092625. Crystal structure of the full-length ATPase GspE from the Vibrio vulnificus type II secretion system in complex with the cytoplasmic domain of GspL. Lu C, Korotkov KV, Hol WGJ;. J Struct Biol. 2014;187:223-235. (from Pfam)

Date:

2024-10-16

Members of this family include ATPases of type 2 secretion systems (T2SS), type 4 pilin (T4P, often involved in twitching motility), and type 4 secretion systems.

Date:

2024-10-16

GspE/PulE family protein similar to type II secretion system protein E, an essential component of type II systems, and to type IV pilus assembly ATPase PilB

Date:

2024-07-05

This family describes GspE, the E protein of the type II secretion system, also called the main terminal branch of the general secretion pathway. This model separates GspE from the PilB protein of type IV pilin biosynthesis.

Gene:

gspE

Date:

2024-05-30