Protein Family Models

A SWi2/SNF2 ATPase found in polyvalent proteins [1]. [1]. 28559295. Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;. J Bacteriol. 2017; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

The restriction enzyme EcoEI recognises 5'-GAGN(7)ATGC-3' and is composed of the three proteins R, M, and S. The domain described here is found at the C-terminus of the R protein (HsdR) which is required for both nuclease and ATPase activity [1,2]. [1]. 8412658. Conservation of motifs within the unusually variable polypeptide sequences of type I restriction and modification enzymes. Murray NE, Daniel AS, Cowan GM, Sharp PM;. Mol Microbiol 1993;9:133-143. [2]. 10449767. Regulation of endonuclease activity by proteolysis prevents breakage of unmodified bacterial chromosomes by type I restriction enzymes. Makovets S, Doronina VA, Murray NE;. Proc Natl Acad Sci U S A 1999;96:9757-9762. (from Pfam)

Date:

2024-10-16

This HMM described the endonuclease domain of HsdR family type I restriction endonucleases. These enzymes also have RecA-like helicase domains.

Date:

2024-10-16

Date:

2024-08-14

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)

Date:

2024-10-16

The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)

Date:

2024-08-14

type I restriction endonuclease subunit R (restriction) is part of the enzyme that may show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation, and restriction activities; belongs to the DEAD-like helicase superfamily

Date:

2017-03-02