Protein Family Models

This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing. (from Pfam)

Date:

2024-08-14

This entry represents an N-terminal domain found in KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport [1]. The aligned region corresponds to a cytoplasmic part of the protein which functions as the sensor domain responsible for sensing turgor pressure [2]. It recognises C-di-AMP and K+ [3]. [1]. 9226259. The kdp system of Clostridium acetobutylicum: cloning, sequencing, and transcriptional regulation in response to potassium concentration. Treuner-Lange A, Kuhn A, Durre P;. J Bacteriol 1997;179:4501-4512. [2]. 1532388. KdpD and KdpE, proteins that control expression of the kdpABC operon, are members of the two-component sensor-effector class of regulators. Walderhaug MO, Polarek JW, Voelkner P, Daniel JM, Hesse JE, Altendorf K, Epstein W;. J Bacteriol 1992;174:2152-2159. [3]. 34424339. A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators. Matilla MA, Velando F, Martin-Mora D, Monteagudo-Cascales E, Krell T;. FEMS Microbiol Rev. 2022;46:fuab043. (from Pfam)

Date:

2024-10-16

This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. [1]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:

2024-10-16

Dimerisation and phospho-acceptor domain of histidine kinases. [1]. 9989504. Structure of CheA, a signal-transducing histidine kinase. Bilwes AM, Alex LA, Crane BR, Simon MI;. Cell 1999;96:131-141. [2]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:

2024-10-16