Protein Family Models

This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Date:

2024-08-14

Date:

2024-08-14

This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding. (from Pfam)

Date:

2024-08-14

Protein hit regions in this family include the N-terminal region of NP_046758.1, the phage P2 terminase large subunit (a DNA-packing ATPase), as well as regions of various transposases, sigma factors, and other DNA-binding proteins.

Date:

2024-11-08

Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1]. [1]. 7801124. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases [see comments]. Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR;. Science 1994;266:1981-1986. (from Pfam)

Date:

2024-10-16

null

Date:

2021-03-03

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10

Date:

2019-09-10