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VpsR-related response regulator
VpsR appears superficially to be a response regulator, based on extension of its alignment to response regulators AlgB and NrtC all the way to the N-terminus. Instead of being a response regulator with a histidine kinase partner, the sigma-54-dependent transcription factor VpsR directly binds to cyclic-di-GMP. Its regulon includes genes for the biosynthesis of the biofilm matrix component called Vibrio polysaccharide (VPS). [1]. 11160103. VpsR, a Member of the Response Regulators of the Two-Component Regulatory Systems, Is Required for Expression of vps Biosynthesis Genes and EPS(ETr)-Associated Phenotypes in Vibrio cholerae O1 El Tor. Yildiz FH, Dolganov NA, Schoolnik GK;. J Bacteriol. 2001;183:1716-1726. (from Pfam)
Sigma-54 interaction domain
helix-turn-helix domain-containing protein
sigma 54-interacting transcriptional regulator
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