Protein Family Models

The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576). [1]. 16462750. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Ramazzina I, Folli C, Secchi A, Berni R, Percudani R;. Nat Chem Biol. 2006;2:144-148. (from Pfam)

Date:

2024-10-16

Previously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus [1]. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model.

Gene:

uraD

Date:

2024-05-15