Protein Family Models

This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities [1-3]. [1]. 7925471. Structural and catalytic properties of the four phenylalanine ammonia-lyase isoenzymes from parsley (Petroselinum crispum Nym.). Appert C, Logemann E, Hahlbrock K, Schmid J, Amrhein N;. Eur J Biochem. 1994;225:491-499. [2]. 10220322. Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile. Schwede TF, Retey J, Schulz GE;. Biochemistry. 1999;38:5355-5361. [3]. 16793524. Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5. Rachid S, Krug D, Kunze B, Kochems I, Scharfe M, Zabriskie TM, Blocker H, Muller R;. Chem Biol. 2006;13:667-681. (from Pfam)

Date:

2024-10-16

This enzyme deaminates histidine to urocanic acid, the first step in histidine degradation. It is closely related to phenylalanine ammonia-lyase.

Gene:

hutH

Date:

2024-05-30

Catalyzes the degradation of histidine to urocanate and ammmonia

Date:

2020-10-26