This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2]. [1]. 9344668. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. Jin-Hua P, Goding JW, Nakamura H, Sano K;. Genomics 1997;45:412-415. [2]. 8617788. Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. Peiffer WE, Desrosiers MG, Menick DR;. J Biol Chem 1996;271:5095-5100. [3]. 7730366. Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. Deissler H, Lottspeich F, Rajewsky MF;. J Biol Chem 1995;270:9849-9855. [4]. 7982964. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME, Liotta LA, Stracke ML;. J Biol Chem 1994;269:30479-30484. (from Pfam)
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- 2024-10-16