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Lar family restriction alleviation protein
This family includes the restriction alleviation protein Lar encoded by the Rac prophage of Escherichia coli, Swiss:P33229. This protein modulates the activity of the Escherichia coli restriction and modification system [1]. [1]. 7476171. Restriction alleviation and modification enhancement by the Rac prophage of Escherichia coli K-12. King G, Murray NE;. Mol Microbiol. 1995;16:769-777. (from Pfam)
Restriction alleviation proteins provide a countermeasure to host cell restriction enzyme defense against foreign DNA such as phage or plasmids. This family consists of homologs to the phage antirestriction protein Lar, and most members belong to phage genomes or prophage regions of bacterial genomes.
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