Protein Family Models

This family matches three types of P-loop containing kinases: phosphoribulokinases [1], uridine kinases [2] and bacterial pantothenate kinases(CoaA) [3]. Arabidopsis and other organisms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain [4]. [1]. 9548738. The crystal structure of phosphoribulokinase from Rhodobacter sphaeroides reveals a fold similar to that of adenylate kinase. Harrison DH, Runquist JA, Holub A, Miziorko HM;. Biochemistry 1998;37:5074-5085. [2]. 8366067. Location of the udk gene on the physical map of Escherichia coli. Neuhard J, Tarpo L;. J Bacteriol. 1993;175:5742-5743. [3]. 1328157. Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli. Song WJ, Jackowski S;. J Bacteriol. 1992;174:6411-6417. [4]. 17143579. Functional characterization of a gene encoding a dual domain for uridine kinase and uracil phosphoribosyltransferase in Arabidopsis thaliana. Islam MR, Kim H, Kang SW, Kim JS, Jeong YM, Hwang HJ, Lee SY, Woo JC, Kim SG;. Plant Mol Biol. 2007;63:465-477. (from Pfam)

Date:

2024-10-16

Shown to be a homodimer in E. coli. This enzyme catalyzes the rate-limiting step in the biosynthesis of coenzyme A. It is very well conserved from E. coli to B. subtilis, but differs considerably from known eukaryotic forms, described in a separate model.

Gene:

coaA

Date:

2021-04-27

type I pantothenate kinase catalyzes the phosphorylation of (R)-pantothenate to form (R)-4'-phosphopantothenate, the first of five steps in coenzyme A biosynthesis

Date:

2017-06-14