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SMI1/KNR4 family protein
Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins. (from Pfam)
Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation [1][2]. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems [3]. [1]. 7937796. Cloning and characterization of a Neurospora crassa gene required for (1,3) beta-glucan synthase activity and cell wall formation. Enderlin CS, Selitrennikoff CP;. Proc Natl Acad Sci U S A. 1994;91:9500-9504. [2]. 8289782. Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong Z, Mann P, Brown NH, Tran LE, Shaw KJ, Hare RS, DiDomenico B;. Mol Cell Biol. 1994;14:1017-1025. [3]. 21306995. A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. Zhang D, Iyer LM, Aravind L;. Nucleic Acids Res. 2011;39:4532-4552. (from Pfam)
SMI1/KNR4 family protein may be involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation
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