Protein Family Models

This family consists of several bacterial intracellular growth attenuator (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria [1]. [1]. 11553591. Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation. Cano DA, Martinez-Moya M, Pucciarelli MG, Groisman EA, Casadesus J, Garcia-Del Portillo F;. Infect Immun 2001;69:6463-6474. [2]. 12524328. Regulation of capsule synthesis and cell motility in Salmonella enterica by the essential gene igaA. Cano DA, Dominguez-Bernal G, Tierrez A, Garcia-Del Portillo F, Casadesus J;. Genetics 2002;162:1513-1523. (from Pfam)

Date:

2024-10-16

intracellular growth attenuator family protein similar to Salmonella enterica IgaA, which is involved in the control of bacterial proliferation in fibroblasts, and Proteus mirabilis UmoB, which acts as a positive regulator of flagellar flhDC master operon

Date:

2016-10-17

Gene:

igaA

Date:

2019-11-13