Protein Family Models

The FliL protein controls the rotational direction of the flagella during chemotaxis [1]. FliL is a cytoplasmic membrane protein associated with the basal body [2]. This protein is a component of the flagellar motor and it is known to enhance the motor performance under high-load conditions in some bacteria. The periplasmic domain of FliL (Flil_C) share significant structural similarity with stomatin/prohibitin/flotillin/HflK/C domains of scaffolding proteins, suggesting that FliL acts as a scaffold [3]. The Flil_C domain is capable of forming a ring assembly with an inner diameter that is comparable in size to the stator unit [3,4]. [1]. 3519573. Sequence of the flaA (cheC) locus of Escherichia coli and discovery of a new gene. Kuo SC, Koshland DE Jr;. J Bacteriol 1986;166:1007-1012. [2]. 10439416. FliL is a membrane-associated component of the flagellar basal body of Salmonella. Schoenhals GJ, Macnab RM;. Microbiology 1999;145:1769-1775. [3]. 35046042. The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation. Tachiyama S, Chan KL, Liu X, Hathroubi S, Peterson B, Khan MF, Ottemann KM, Liu J, Roujeinikova A;. Proc Natl Acad Sci U S A. 2022;119:e2118401119. [4]. 30890608. Structure of Vibrio FliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function. Takekawa N, Isumi M, Terashima H, Zhu S, Nishino Y, Sakuma M, Kojima S, Homma M, Imada K;. mBio. 2019;10:e00292-e00219. (from Pfam)

Date:

2024-10-16

Interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring

Gene:

fliL

Date:

2022-07-19

flagellar basal body-associated protein FliL interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring

Date:

2015-09-11