Protein Family Models

The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The C-terminal metal binding domain has a rubredoxin-like fold and provides the interface with the catalytic chain. [1]. 364472. Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate. Monaco HL, Crawford JL, Lipscomb WN;. Proc Natl Acad Sci U S A 1978;75:5276-5280. [2]. 10651286. Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A. Jin L, Stec B, Lipscomb WN, Kantrowitz ER;. Proteins 1999;37:729-742. (from Pfam)

Date:

2024-10-16

The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The N-terminal domain has ferredoxin-like fold, and provides the regulatory chain dimerisation interface. [1]. 364472. Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and of its complex with cytidine triphosphate. Monaco HL, Crawford JL, Lipscomb WN;. Proc Natl Acad Sci U S A 1978;75:5276-5280. [2]. 10651286. Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A. Jin L, Stec B, Lipscomb WN, Kantrowitz ER;. Proteins 1999;37:729-742. (from Pfam)

Date:

2024-10-16

aspartate carbamoyltransferase regulatory subunit is involved in the allosteric regulation of aspartate carbamoyltransferase

Date:

2017-02-03

The presence of this regulatory subunit allows feedback inhibition by CTP on aspartate carbamoyltransferase, the first step in the synthesis of CTP from aspartate. In many species, this regulatory subunit is not present. In Thermotoga maritima, the catalytic and regulatory subunits are encoded by a fused gene and the regulatory region has enough sequence differences to score below the trusted cutoff.

Gene:

pyrI

Date:

2024-05-28