Protein Family Models

This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit [1]. [1]. 12670970. Bacteriophage SPP1 Chu is an alkaline exonuclease in the SynExo family of viral two-component recombinases. Vellani TS, Myers RS;. J Bacteriol. 2003;185:2465-2474. (from Pfam)

Date:

2024-10-16

lambda exonuclease family protein similar to Escherichia phage Lambda exonuclease, which facilitates phage DNA recombination through the double-strand break repair (DSBR) and single-strand annealing pathways; also important for the late, rolling-circle mode of lambda DNA replication

Date:

2024-01-09