Protein Family Models

CBP_BcsG is a component of bacterial cellulose synthase complex that plays a role in biofilm formation in bacteria [1]. It is a Zn(2+)-dependent phosphoethanolamine transferase that catalyses transfer of phosphoethanolamine residues from membrane phosphatidylethanolamine to the glucosyl residues in the nascent cellulose chain [2-5]. [1]. 26077867. Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions. Romling U, Galperin MY;. Trends Microbiol. 2015;23:545-557. [2]. 29348238. Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose. Thongsomboon W, Serra DO, Possling A, Hadjineophytou C, Hengge R, Cegelski L;. Science. 2018;359:334-338. [3]. 29348224. A bacterial coat that is not pure cotton. Galperin MY, Shalaeva DN;. Science. 2018;359:276-277. [4]. 30017920. Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium. Sun L, Vella P, Schnell R, Polyakova A, Bourenkov G, Li F, Cimdins A, Schneider TR, Lindqvist Y, Galperin MY, Schneider G, Romling U;. J Mol Biol. 2018;430:3170-3189. [5]. 32152228. The Escherichia coli cellulose synthase subunit G (BcsG) is a Zn(2+)-dependent phosphoethanolamine transferase. Anderson AC, Burnett AJN, Hiscock L, Maly KE, Weadge JT;. J Biol Chem. 2020;295:6225-6235. (from Pfam)

Gene:

bcsG

Date:

2024-10-16

This protein was identified by the partial phylogenetic profiling algorithm (PMID:16930487) as part of the system for cellulose biosynthesis in bacteria, and in fact is found in cellulose biosynthesis gene regions. The protein was designated YhjU in Salmonella enteritidis, where disruption of its gene disrupts cellulose biosynthesis and biofilm formation (PMID:11929533).

Gene:

bcsG

Date:

2024-08-07

cellulose biosynthesis protein BcsG

Date:

2019-06-25