Protein Family Models

T3SSipB is a family of pathogenic Gram-negative bacterial proteins that invade human intestinal cells via the type III secretion system translocators. T3SSipB represents the coiled -coil region of the proteins and is shown to be homologous in activity to the pore-forming toxins of other Gram-negative pathogens, such as colicin Ia [1-8]. [1]. 8801431. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells. Hermant D, Menard R, Arricau N, Parsot C, Popoff MY;. Mol Microbiol. 1995;17:781-789. [2]. 7608068. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. Kaniga K, Tucker S, Trollinger D, Galan JE;. J Bacteriol. 1995;177:3965-3971. [3]. 10051653. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Hersh D, Monack DM, Smith MR, Ghori N, Falkow S, Zychlinsky A;. Proc Natl Acad Sci U S A. 1999;96:2396-2401. [4]. 10972796. Membrane fusion activity of purified SipB, a Salmonella surface protein essential for mammalian cell invasion. Hayward RD, McGhie EJ, Koronakis V;. Mol Microbiol. 2000;37:727-739. [5]. 14662750. A Salmonella protein causes macrophage cell death by inducing autophagy. Hernandez LD, Pypaert M, Flavell RA, Galan JE;. J Cell Biol. 2003;163:1123-1131. [6]. 16159789. Multinucleated giant cell formation and apoptosis in infected host cells is mediated by Burkholderia pseudomallei type III secretion protein BipB. Suparak S, Kespichayawattana W, Haque A, Easton A, Damnin S, Lertmemongkolchai G, Bancroft GJ, Korbsrisate S;. J Bacteriol. 2005;187:6556-6560. [7]. 22975346. Membr. TRUNCATED at 1650 bytes (from Pfam)

Date:

2025-01-31

SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella. All these proteins are secreted by the type III secretion system [1]. Many mucosal pathogens use type III secretion systems for the injection of effector proteins into target cells. SecB, SseC and SecD are inserted into the target cell membrane. where they form a small pore or translocon [1,2]. In addition to SseC, this family includes the bacterial secreted proteins PopB, PepB, YopB and EspD which are thought to be directly involved in pore formation, and type III secretion system translocon. [1]. 11580752. Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli. Ide T, Laarmann S, Greune L, Schillers H, Oberleithner H, Schmidt MA;. Cell Microbiol 2001;3:669-679. [2]. 26520801. Type III Secretion: Building and Operating a Remarkable Nanomachine. Portaliou AG, Tsolis KC, Loos MS, Zorzini V, Economou A;. Trends Biochem Sci. 2016;41:175-189. (from Pfam)

Gene:

sctE

Date:

2025-02-02

protein similar to cell invasion protein SipB

Date:

2017-03-02

Date:

2020-10-26

Gene:

sipB

Date:

2019-11-13