Protein Family Models

This family includes eukaryotic fructosamine-3-kinase enzymes [1]. The family also includes bacterial members that have not been characterised but probably have a similar or identical function. [1]. 11016445. Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase. Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E;. Diabetes 2000;49:1627-1634. (from Pfam)

Date:

2024-10-16

This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation [2]. This family also includes homoserine kinase. This family is related to fructosamine kinase Pfam:PF03881. [1]. 2163618. Cloning of aminoglycoside phosphotransferase (APH) gene from antibiotic- producing strain of Bacillus circulans into a high-expression vector, pKK223-3. Purification, properties and location of the enzyme [published erratum appears in Biochem J 1991 Feb 1. Sarwar M, Akhtar M;. Biochem J 1990;268:671-677. [2]. 2167474. PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475. Trower MK, Clark KG;. Nucleic Acids Res 1990;18:4615-4615. (from Pfam)

Date:

2024-10-16

fructosamine kinase family protein such as protein-ribulosamine 3-kinase, which catalyzes the phosphorylation of protein-bound ribulosamines that become unstable as a consequence and detach from proteins

Date:

2016-04-22