Protein Family Models for Protein (Select 446205501) - Protein Family Models

Select item 4294371.

This entry represents the C-terminal helical domain of SirC from Bacillus megaterium and related sequences [1]. This domain contains Arg159 which contributes to the active site from the alternate molecule of the homodimer. Paper describing PDB structure 3dfz. [1]. 18588505. Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase. Schubert HL, Rose RS, Leech HK, Brindley AA, Hill CP, Rigby SE, Warren MJ;. Biochem J. 2008;415:257-263. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF046278.1
Method:: HMM

Select item 4245542.

Sirohaem biosynthesis protein central

This is the central domain of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241 [1]. [1]. 11980703. The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase. Schubert HL, Raux E, Brindley AA, Leech HK, Wilson KS, Hill CP, Warren MJ;. EMBO J. 2002;21:2068-2075. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF026174.5
Method:: HMM

Select item 4220273.

NAD(P)-dependent oxidoreductase

This domain is found in fungi, plants, archaea and bacteria. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024638.5
Method:: HMM

Select item 4015464.

new record, indexing in progress

Family Accession:

Select item 4001915.

new record, indexing in progress

Family Accession:

Select item 3671926.

NAD(P)-binding protein

NAD(P)-binding protein may be an FAD-dependent enzyme that catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Date:: 2023-10-10

Family Accession:: 11482400
Method:: Sparcle

Select item 3634837.

new record, indexing in progress

Family Accession:

Select item 3582188.

new record, indexing in progress

Family Accession:

Select item 1415729.

siroheme synthase, N-terminal domain

This HMM represents a subfamily of CysG N-terminal region-related sequences. All sequences in the seed alignment for this model are N-terminal regions of known or predicted siroheme synthases. The C-terminal region of each is uroporphyrin-III C-methyltransferase (EC 2.1.1.107), which catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). The region represented by this model completes the process of oxidation and iron insertion to yield siroheme. Siroheme is a cofactor for nitrite and sulfite reductases, so siroheme synthase is CysG of cysteine biosynthesis in some organisms.

GO Terms:

Biological Process:: siroheme biosynthetic process (GO:0019354)

Molecular Function:: precorrin-2 dehydrogenase activity (GO:0043115)

Molecular Function:: sirohydrochlorin ferrochelatase activity (GO:0051266)

Date:: 2021-04-27

Family Accession:: TIGR01470.1
Method:: HMM

Select item 1774910.

NAD(P)-binding protein

Date:: 2020-10-26

Family Accession:: NF005222.0
Method:: HMM

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