Protein Family Models for Protein (Select 446210521) - Protein Family Models

Select item 4158791.

AlkA N-terminal domain-containing protein

Date:: 2024-08-14

Family Accession:: NF017809.5
Method:: HMM

Select item 4114552.

HhH-GPD superfamily base excision DNA repair protein

This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [2]. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases such as Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7 also contains a related domain [1] that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family. [1]. 10499592. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A;. Nature 1999;401:301-304. [2]. 10706276. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Bruner SD, Norman DP, Verdine GL;. Nature 2000;403:859-866. (from Pfam)

GO Terms:

Biological Process:: base-excision repair (GO:0006284)

Date:: 2024-10-16

Family Accession:: NF012933.5
Method:: HMM

Select item 3942603.

new record, indexing in progress

Family Accession:

Select item 3885734.

new record, indexing in progress

Family Accession:

Select item 3521745.

new record, indexing in progress

Family Accession:

Select item 3469876.

new record, indexing in progress

Family Accession:

Select item 2154587.

DNA-3-methyladenine glycosylase 2

DNA-3-methyladenine glycosylase 2 (TAG II) catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA

Date:: 2017-03-24

Family Accession:: 11484652
Method:: Sparcle

Select item 1732798.

DNA-3-methyladenine glycosylase 2

Inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine

Gene:: alkA

GO Terms:

Molecular Function:: catalytic activity (GO:0003824)

Biological Process:: DNA repair (GO:0006281)

Date:: 2021-09-15

Family Accession:: NF007641.0
Method:: HMM

Protein Family Models

Protein Family

Send to:

Links from Protein

Items: 8

Send to:

Supplemental Content

Find related data

Recent activity