Protein Family Models

This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif. (from Pfam)

Date:

2024-08-14

This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster [1]. In pipsqueak this domain binds to GAGA sequence [1]. [1]. 9774480. The pipsqueak protein of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain. Lehmann M, Siegmund T, Lintermann KG, Korge G;. J Biol Chem 1998;273:28504-28509. [2]. 11976954. The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins. Siegmund T, Lehmann M;. Dev Genes Evol 2002;212:152-157. [3]. 11731471. The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis. Shim K, Blake KJ, Jack J, Krasnow MA;. Development 2001;128:4923-4933. (from Pfam)

Date:

2024-10-16

Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1]. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives. [1]. 11931761. Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Campbell EA, Muzzin O, Chlenov M, Sun JL, Olson CA, Weinman O, Trester-Zedlitz ML, Darst SA;. Mol Cell 2002;9:527-539. (from Pfam)

Date:

2024-10-16