Protein Family Models

Date:

2024-08-14

This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2. (from Pfam)

Date:

2024-08-14

This family contains alpha/beta hydrolase enzymes of diverse specificity. (from Pfam)

Date:

2024-08-14

Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile [1]. This family has an alpha-beta hydrolase fold [2,3]. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family [3]. [1]. 20080647. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA;. Proc Natl Acad Sci U S A. 2010;107:2189-2194. [2]. 15159570. Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution. Janda I, Devedjiev Y, Cooper D, Chruszcz M, Derewenda U, Gabrys A, Minor W, Joachimiak A, Derewenda ZS;. Acta Crystallogr D Biol Crystallogr 2004;60:1101-1107. [3]. 19004028. Crystal structure of human retinoblastoma binding protein 9. Vorobiev SM, Su M, Seetharaman J, Huang YJ, Chen CX, Maglaqui M, Janjua H, Proudfoot M, Yakunin A, Xiao R, Acton TB, Montelione GT, Tong L;. Proteins. 2009;74:526-529. (from Pfam)

Date:

2024-10-16

This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila. A sequence-related jojoba acyl CoA reductase is also included. [1]. 9351246. The Arabidopsis MALE STERILITY 2 protein shares similarity with reductases in elongation/condensation complexes. Aarts MG, Hodge R, Kalantidis K, Florack D, Wilson ZA, Mulligan BJ, Stiekema WJ, Scott R, Pereira A;. Plant J 1997;12:615-623. (from Pfam)

Date:

2024-10-16

This is a family of diverse bacterial polysaccharide biosynthesis proteins including the CapD protein (Swiss:P39853) [1], WalL protein (Swiss:O86159) mannosyl-transferase (Swiss:O05349) [2] and several putative epimerases (e.g. WbiI Swiss:O69130). [1]. 7961465. Sequence analysis and molecular characterization of genes required for the biosynthesis of type 1 capsular polysaccharide in Staphylococcus aureus. Lin WS, Cunneen T, Lee CY;. J Bacteriol 1994;176:7005-7016. [2]. 9079898. Identification of additional genes required for O-antigen biosynthesis in Vibrio cholerae O1. Fallarino A, Mavrangelos C, Stroeher UH, Manning PA;. J Bacteriol 1997;179:2147-2153. (from Pfam)

Date:

2024-10-16

This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions. [1]. 9174344. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM;. Biochemistry 1997;36:6294-6304. (from Pfam)

Date:

2024-10-16

This catalytic domain is found in a very wide range of enzymes. [1]. 1409539. The alpha/beta hydrolase fold. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A;. Protein Eng 1992;5:197-211. (from Pfam)

Date:

2024-10-16