Protein Family Models

This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [1]. TctA is part of the tripartite TctABC system which, as characterised in S. typhimurium [2], is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules [1]. [1]. 14499931. The tripartite tricarboxylate transporter (TTT) family. Winnen B, Hvorup RN, Saier MH Jr;. Res Microbiol. 2003;154:457-465. [2]. 6141166. Tricarboxylate-binding proteins of Salmonella typhimurium. Purification, crystallization, and physical properties. Sweet GD, Kay CM, Kay WW;. J Biol Chem. 1984;259:1586-1592. (from Pfam)

Date:

2024-10-16

tripartite tricarboxylate transporter (TTT) permease similar to TctA, which is part of the tripartite TctABC system, a secondary carrier composed of an extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB

Date:

2024-08-07