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Shikimate 5'-dehydrogenase C-terminal domain
This domain is found in the C-terminal region of Shikimate 5'-dehydrogenase (SDH) present in Methanocaldococcus jannaschii. SDH catalyses the NADPH-dependent reduction of 3-dehydroshikimate to shikimate in the shikimate pathway. The domain is found just after the C-terminal domain (Pfam:PF01488) which is responsible for NADP binding [1]. [1]. 19215302. X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. Han C, Hu T, Wu D, Qu S, Zhou J, Ding J, Shen X, Qu D, Jiang H;. FEBS J. 2009;276:1125-1139. (from Pfam)
Shikimate dehydrogenase substrate binding domain
This domain is the substrate binding domain of shikimate dehydrogenase [1]. [1]. 15735308. Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D;. J Biol Chem 2005;280:17101-17108. (from Pfam)
quinate/shikimate dehydrogenase
quinate/shikimate dehydrogenase catalyzes the reversible NAD(P)-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively
Converts quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate
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