This entry includes AimR transcriptional regulator from Bacillus phage and related sequences found in tailed bacteriophages and prophages. AimR (arbitrium receptor), which is a part of the so-called phage arbitrium system, is a DNA-binding phage regulatory protein that acts as a receptor for a 6-amino acid signaling peptide cleaved rom the C terminus of AimP. AimR controls expression of AimX, the third member of the quorum sensing-like arbitrium system and an inhibitor of phage lysogeny [1]. AimR assembles in an alpha-alpha superhelix fold and accommodates the signaling peptide encircled by its tetratricopeptide repeats, which is reminiscent of RRNPP family members from the quorum-sensing system [2,3]. [1]. 28099413. Communication between viruses guides lysis-lysogeny decisions. Erez Z, Steinberger-Levy I, Shamir M, Doron S, Stokar-Avihail A, Peleg Y, Melamed S, Leavitt A, Savidor A, Albeck S, Amitai G, Sorek R;. Nature. 2017;541:488-493. [2]. 30224798. Structural basis of the arbitrium peptide-AimR communication system in the phage lysis-lysogeny decision. Wang Q, Guan Z, Pei K, Wang J, Liu Z, Yin P, Peng D, Zou T;. Nat Microbiol. 2018;3:1266-1273. [3]. 30745087. Deciphering the Molecular Mechanism Underpinning Phage Arbitrium Communication Systems. Gallego Del Sol F, Penades JR, Marina A;. Mol Cell. 2019;74:59-72. (from Pfam)
- Date:
- 2024-10-16