Protein Family Models

Laccases are multi-copper oxidoreductases able to oxidise a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms [1]. [1]. 16740638. Novel polyphenol oxidase mined from a metagenome expression library of bovine rumen: biochemical properties, structural analysis, and phylogenetic relationships. Beloqui A, Pita M, Polaina J, Martinez-Arias A, Golyshina OV, Zumarraga M, Yakimov MM, Garcia-Arellano H, Alcalde M, Fernandez VM, Elborough K, Andreu JM, Ballesteros A, Plou FJ, Timmis KN, Ferrer M, Golyshin PN;. J Biol Chem. 2006;281:22933-22942. (from Pfam)

Date:

2024-10-16

polyphenol oxidase/laccase family protein such as peptidoglycan editing factor PgeF involved in the maintenance of bacterial peptide composition; may bind copper and oxidize one or more of a variety of phenolic and non-phenolic compounds

Date:

2024-11-29

PSI-BLAST converges on members of this family of uncharacterized bacterial proteins and shows no significant similarity to any characterized protein. No completed genome to date has two members. Members of the family have been crystallized but the function is unknown.

Gene:

pgeF

Date:

2019-09-10