Protein Family Models

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Date:

2024-04-02

The bacterial PIcR helix-turn-helix transcription factor includes five TPR units of different lengths [1]. This entry represents the TPR containing domain as a whole. This family is called RNPP after (Rapm NprR, PrgX, and PlcR). [1]. 23277548. Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. Grenha R, Slamti L, Nicaise M, Refes Y, Lereclus D, Nessler S;. Proc Natl Acad Sci U S A. 2013;110:1047-1052. (from Pfam)

Date:

2024-10-16

Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains. (from Pfam)

Date:

2024-08-14

This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1]. [1]. 20196080. The crystal structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif. Ren J, Sainsbury S, Nettleship JE, Saunders NJ, Owens RJ;. Proteins. 2010;78:1798-1802. (from Pfam)

Date:

2024-10-16