Protein Family Models

This entry represents the HTTM (for horizontally transferred transmembrane) domain found at the N-terminal in metazoan Vitamin K-dependent gamma-carboxylase and in diverse domain architectures in bacterial proteins. This domain shows four transmembrane regions [2]. [1]. 10748045. Identification of a Drosophila vitamin K-dependent gamma-glutamyl carboxylase. Li T, Yang CT, Jin D, Stafford DW;. J Biol Chem 2000;275:18291-18296. [2]. 14729325. HTTM, a horizontally transferred transmembrane domain. Schultz J;. Trends Biochem Sci. 2004;29:4-7. (from Pfam)

Date:

2024-10-16

Members of this family have two highly conserved cysteine residues within the DxxCxxC motif at the N-terminal. This motif is conserved in the thiol-disulfide oxidoreductase family [1]. This family includes At5g50100 (also known as DCC1) from Arabidopsis thaliana, a thioredoxin that modulates ROS homeostasis resulting in de novo shoot initiation and may be involved in the improvement of the capacity of plant regeneration [1]. Uncharacterised proteins from bacteria are also included in this family. [1]. 28724620. Thioredoxin-Mediated ROS Homeostasis Explains Natural Variation in Plant Regeneration. Zhang H, Zhang TT, Liu H, Shi Y, Wang M, Bie XM, Li XG, Zhang XS;. Plant Physiol. 2018;176:2231-2250. (from Pfam)

Date:

2024-10-16

HTTM and DUF393 domain-containing protein

Date:

2017-03-02