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Helix-turn-helix domain
The TyrR protein of Haemophilus influenzae is a 36-kD transcription factor whose major function is to control the expression of genes important in the biosynthesis and transport of aromatic amino acids [1]. This entry represents the C-terminal helix-turn-helix DNA-binding domain of TyrR and related proteins. [1]. 11344327. Solution structure of the DNA-binding domain of the TyrR protein of Haemophilus influenzae. Wang Y, Zhao S, Somerville RL, Jardetzky O;. Protein Sci. 2001;10:592-598. (from Pfam)
Sigma-54 interaction domain
PAS domain-containing protein
PAS domains are involved in many signalling proteins where they are used as a signal sensor domain [1]. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognises oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 10357859. PAS domains: internal sensors of oxygen, redox potential, and light. Taylor BL, Zhulin IB;. Microbiol Mol Biol Rev. 1999;63:479-506. (from Pfam)
AAA family ATPase
This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model. [1]. 7646486. A 200-amino acid ATPase module in search of a basic function. Confalonieri F, Duguet M;. Bioessays 1995;17:639-650. A large extension of the family. [2]. 9927482. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Neuwald AF, Aravind L, Spouge JL, Koonin EV;. Genome Res 1999;9:27-43. (from Pfam)
helix-turn-helix domain-containing protein
sigma 54-interacting transcriptional regulator
sigma-54 interaction domain-containing protein
sigma-54 interaction domain-containing protein may be a sigma-54 dependent transcriptional regulator similar to FisR, NtrC, NifA, and RocR
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