Protein Family Models

This family consists of the C-terminal helix-turn-helix domain found in several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2]. [1]. 7783641. A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon. Slack FJ, Serror P, Joyce E, Sonenshein AL;. Mol Microbiol 1995;15:689-702. [2]. 11401725. Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in Lactococcus lactis. Guedon E, Serror P, Ehrlich SD, Renault P, Delorme C;. Mol Microbiol 2001;40:1227-1239. (from Pfam)

Date:

2024-10-16

This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. This domain is involved in GTP binding and also branched chain amino acids (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2]. [1]. 7783641. A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon. Slack FJ, Serror P, Joyce E, Sonenshein AL;. Mol Microbiol 1995;15:689-702. [2]. 11401725. Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in Lactococcus lactis. Guedon E, Serror P, Ehrlich SD, Renault P, Delorme C;. Mol Microbiol 2001;40:1227-1239. (from Pfam)

Date:

2024-10-16

GTP-sensing pleiotropic transcriptional regulator CodY is a DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation

Date:

2019-06-26

Gene:

codY

Date:

2018-10-02

Gene:

codY

Date:

2021-09-27

This model represents the full length of CodY, a pleiotropic repressor in Bacillus subtilis and other Firmicutes (low-GC Gram-positive bacteria) that responds to intracellular levels of GTP and branched chain amino acids. The C-terminal helix-turn-helix DNA-binding region is modeled by PF08222 in Pfam.

Gene:

codY

Date:

2024-05-16